Author

C. Mattos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Assay:protein structure· 1

Frequent Co-Authors

C. W. Johnson· 2 shared T. Cookis· 2 shared A. Liu· 1 shared C. B. Marshall· 1 shared D. K. Morrison· 1 shared D. P. Donnelly· 1 shared E. A. Geffken· 1 shared E. M. Terrell· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

C. W. Johnson

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Allosteric site variants affect GTP hydrolysis on RAS

C. W. Johnson, S. K. Fetics, K. P. Davis, J. A. Rodrigues, C. Mattos

The paper investigates how mutations in an allosteric site of HRAS affect GTP hydrolysis and shows that structural changes correlate with enzymatic activity and RAF-RBD binding.

bioRxiv · May 29, 2023Biochemistry

Crystal structure reveals the full Ras:Raf interface and advances mechanistic understanding of Raf activation

T. Cookis, C. Mattos

The paper presents the crystal structure of the HRas/CRaf-RBD_CRD complex and proposes a model for Ras-mediated Raf activation through structural and simulation analysis.

Biomolecules · Jul 7, 2021Peer-reviewedBiophysics

Regulation of GTPase function by autophosphorylation

C. W. Johnson, H.-S. Seo, E. M. Terrell, F. KleinJan, T. Gebregiworgis, G. M. C. Gasmi-Seabrook, E. A. Geffken, J. Lakhani, K. Song, O. Popow, J. A. Paulo, A. Liu, C. Mattos, C. B. Marshall, M. Ikura, , K. M. Haigis

This study shows autophosphorylation of small GTPases like H-RAS and K-RAS alters their nucleotide exchange and effector interactions, changing their functional behavior.

bioRxiv · Jun 23, 2021Biochemistry

Raf promotes dimerization of the Ras G-domain with increased allosteric connections

M. Packer, J. A. Parker, J. K. Chung, Z. Li, Y. K. Lee, T. Cookis, H. Guterres, S. Alvarez, M. A. Hossain, D. P. Donnelly, J. N. Agar, L. Makowski, M. Buck, J. T. Groves, C. Mattos

This study shows Raf-RBD induces Ras dimerization and identifies allosteric connections between Raf-RBD residues that contribute to signaling complex formation.

Proceedings of the National Academy of Sciences · Mar 9, 2021Peer-reviewedBiophysics