Transcriptomic analysis of human and mouse muscle during hyperinsulinemia demonstrates insulin receptor downregulation as a mechanism for insulin resistance
H. H. Cen, J. D. Botezelli, S. Wang, N. Noursadeghi, N. Jessen, J. D. Johnson, J. A. Timmons
The paper investigates how prolonged insulin exposure affects muscle cells, finding that reduced insulin receptor expression contributes to insulin resistance.
bioRxiv · Mar 21, 2021 · PreprintPhysiology