H. H. Cen

Pharmacological or genetic inhibition of Scn9a protects human and mouse beta cells while dampening insulin secretion in type 1 diabetes

This study shows that inhibiting Scn9a protects beta cells in type 1 diabetes by reducing excitability and improving survival, while also dampening insulin secretion.

Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and inflammation

Insulin receptor trafficking and interactions in muscle cells

This study investigates insulin receptor trafficking and interactions in muscle cells, identifying caveolin and clathrin-mediated pathways involved in receptor dynamics.

Transcriptomic analysis of human and mouse muscle during hyperinsulinemia demonstrates insulin receptor downregulation as a mechanism for insulin resistance

The paper investigates how prolonged insulin exposure affects muscle cells, finding that reduced insulin receptor expression contributes to insulin resistance.

Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing translation inhibition.

This study shows EIF2A protects pancreatic beta cells from ER stress by rescuing translation inhibition and reducing apoptosis.

Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance

This study shows that deleting the insulin receptor in beta-cells improves glucose tolerance in some mice but not others, depending on age and diet.

Differential effects of voclosporin and tacrolimus on insulin secretion from human islets

This study compares the effects of voclosporin and tacrolimus on insulin secretion from human islets, finding that tacrolimus impairs insulin secretion while voclosporin does not.