Author

J. D. Botezelli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Physiology· 3

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Research Focus:differential expression· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

J. D. Johnson· 3 shared H. H. Cen· 2 shared N. Noursadeghi· 2 shared P. Overby· 2 shared A. Bautista· 1 shared B. Gablaski· 1 shared C. Cras-Meneur· 1 shared C. E. Ellis· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersPhysiology

J. D. Johnson

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3 papers

Recent·Most cited

Transcriptomic analysis of human and mouse muscle during hyperinsulinemia demonstrates insulin receptor downregulation as a mechanism for insulin resistance

H. H. Cen, J. D. Botezelli, S. Wang, N. Noursadeghi, N. Jessen, J. D. Johnson, J. A. Timmons

The paper investigates how prolonged insulin exposure affects muscle cells, finding that reduced insulin receptor expression contributes to insulin resistance.

bioRxiv · Mar 21, 2021 · PreprintPhysiology

Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance

S. Skovso, E. Panzhinskiy, J. Kolic, H. H. Cen, D. A. Dionne, X.-Q. Dai, R. B. Sharma, L. Elghazi, C. E. Ellis, K. Faulkner, S. A. M. Marcil, P. Overby, N. Noursadeghi, D. Hutchinson, X. Hu, , J. D. Johnson

This study shows that deleting the insulin receptor in beta-cells improves glucose tolerance in some mice but not others, depending on age and diet.

bioRxiv · Oct 15, 2020Physiology

Adipose depot-specific upregulation of Ucp1 or mitochondrial oxidative complex proteins are early consequences of genetic insulin reduction in mice

J. D. Botezelli, P. Overby, L. Lindo, S. D. Wang, O. Haida, G. E. Lim, N. M. Templeman, J. R. Pauli, J. D. Johnson

This study shows that reducing insulin in mice increases oxidative mitochondrial proteins in inguinal white adipose tissue and upregulates Ucp1 in mesenteric WAT and BAT under high-fat diet conditions.

bioRxiv · Mar 31, 2020Physiology