Author

N. Jessen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Physiology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Assay:metabolomics· 2 Assay:proteomics· 2

Frequent Co-Authors

J. Farup· 2 shared J. Just· 2 shared L. Lin· 2 shared T. Billeskov· 2 shared A. B. Moeller· 1 shared A. J. Ovens· 1 shared A. M. Ehrlich· 1 shared C. Comert· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersPhysiology

J. Farup

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5 papers

Recent·Most cited

Complementing Muscle Regeneration: Fibro-Adipogenic Progenitor and Macrophage-Mediated Repair of Elderly Human Skeletal Muscle

J. Brorson, L. Lin, J. Wang, T. Billeskov, J. Just, J. Hasko, C. Ravn, R. L. Hansen, M. Bue, Y. Luo, N. Jessen, J. Farup

This study identifies fibro-adipogenic progenitors and macrophages as key players in elderly human skeletal muscle regeneration through spatial and single-cell transcriptomics, revealing their interplay via complement factor C3.

bioRxiv · Apr 18, 2024Physiology

Metformin improves glycemia independently of skeletal muscle AMPK via enhanced intestinal glucose clearance

R. Kjobsted, J. M. Kristensen, J. B. Birk, N. O. Jorgensen, K. Kido, N. R. Andersen, J. K. Larsen, M. Foretz, V. Benoit, F. Nielsen, K. Brosen, N. Jessen, Y. Hellsten, K. Hojlund, J. F. P. Wojtaszewski

This study shows metformin reduces blood glucose through improved intestinal glucose clearance, not via skeletal muscle AMPK activation, challenging current understanding of its mechanism.

bioRxiv · May 22, 2022 · PreprintPhysiology

Transcriptomic analysis of human and mouse muscle during hyperinsulinemia demonstrates insulin receptor downregulation as a mechanism for insulin resistance

H. H. Cen, J. D. Botezelli, S. Wang, N. Noursadeghi, N. Jessen, J. D. Johnson, J. A. Timmons

The paper investigates how prolonged insulin exposure affects muscle cells, finding that reduced insulin receptor expression contributes to insulin resistance.

bioRxiv · Mar 21, 2021 · PreprintPhysiology

Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle

P. Rhein, E. M. Desjardins, P. Rong, D. Ahwazi, N. Bonhoure, J. Stolte, M. D. Santos, A. J. Ovens, A. M. Ehrlich, J. L. Sanchez Garcia, Q. Ouyang, M. F. Kjolby, M. Membrez, N. Jessen, J. S. Oakhill, , K. Sakamoto

This study shows that AMPKγ3 is essential for AICAR-induced glucose clearance and uptake in glycolytic muscle but not for ADaM drug-induced effects or adipose thermogenesis.

bioRxiv · Mar 5, 2021Physiology

Human skeletal muscle CD90+ fibro-adipogenic progenitors are associated with muscle degeneration in type 2 diabetes patients

J. Farup, J. Just, F. de Paoli, L. Lin, J. B. Jensen, T. Billeskov, I. S. Roman, C. Comert, A. B. Moeller, L. Madaro, E. Groppa, R. G. Fred, U. Kampmann, S. B. Pedersen, P. Bross, , N. Jessen

This study identifies CD90+ fibro-adipogenic progenitors in T2DM skeletal muscle and shows PDGF signaling drives their pathogenic behavior, which is mitigated by Metformin.

bioRxiv · Aug 25, 2020Cell Biology