Author

N. Noursadeghi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2

Frequent Co-Authors

D. A. Dionne· 3 shared E. Panzhinskiy· 3 shared H. H. Cen· 3 shared J. D. Johnson· 3 shared S. Skovso· 3 shared H. Modi· 2 shared J. D. Botezelli· 2 shared X. Hu· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersPhysiology

D. A. Dionne

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Dynamic Ins2 gene activity defines β-cell maturity states

C. M. J. Chu, H. Modi, S. Skovso, C. Ellis, N. A. J. Krentz, Y. B. Zhao, H. Cen, N. Noursadeghi, E. Panzhinskiy, X. Hu, D. A. Dionne, Y. h. Xia, S. Xuan, M. O. Huising, T. J. Kieffer, , J. Johnson

This study shows that β-cell heterogeneity in insulin production is due to dynamic Ins2 gene activity states, with high activity linked to maturity and reduced viability.

bioRxiv · Jul 18, 2022Cell Biology

Transcriptomic analysis of human and mouse muscle during hyperinsulinemia demonstrates insulin receptor downregulation as a mechanism for insulin resistance

H. H. Cen, J. D. Botezelli, S. Wang, N. Noursadeghi, N. Jessen, J. D. Johnson, J. A. Timmons

The paper investigates how prolonged insulin exposure affects muscle cells, finding that reduced insulin receptor expression contributes to insulin resistance.

bioRxiv · Mar 21, 2021 · PreprintPhysiology

Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing translation inhibition.

E. Panzhinskiy, S. Skovso, H. H. Cen, K. Y. Chu, K. MacDonald, G. Soukhatcheva, D. A. Dionne, L. K. Hallmaier-Wacker, J. S. Wildi, S. Marcil, N. Noursadeghi, F. Taghizadeh, C. B. Verchere, E. Jan, J. D. Johnson

This study shows EIF2A protects pancreatic beta cells from ER stress by rescuing translation inhibition and reducing apoptosis.

bioRxiv · Feb 17, 2021 · PreprintPhysiology

Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance

S. Skovso, E. Panzhinskiy, J. Kolic, H. H. Cen, D. A. Dionne, X.-Q. Dai, R. B. Sharma, L. Elghazi, C. E. Ellis, K. Faulkner, S. A. M. Marcil, P. Overby, N. Noursadeghi, D. Hutchinson, X. Hu, , J. D. Johnson

This study shows that deleting the insulin receptor in beta-cells improves glucose tolerance in some mice but not others, depending on age and diet.

bioRxiv · Oct 15, 2020Physiology