Streptococcus pyogenes M1T1 variants activate caspase-1 and induce an inflammatory neutrophil phenotype
J. G. Williams, D. Ly, N. J. Geraghty, J. D. McArthur, H. Vyas, J. Gorman, J. A. Tsatsaronis, R. Sluyter, M. L. Sanderson-Smith
This study shows that M1T1 GAS variants induce caspase-1 activation and an inflammatory neutrophil phenotype, promoting inflammation but not bacterial clearance.
bioRxiv · Mar 2, 2020 · PreprintMicrobiology