Author

J. Acosta

Primary ORCID profile (0000-0001-8761-6040 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

J. AcostaiD1 paper · Harvard University

Biology Disciplines

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Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A. C. Gladstein· 1 shared A. E. Marcoleta· 1 shared B. Stanger· 1 shared C. Berrios-Pasten· 1 shared D. M. Feldser· 1 shared F. P. Chavez· 1 shared G. P. Grothusen· 1 shared H. Mai· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. C. Gladstein

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Population genomics, resistance, pathogenic potential, and mobile genetic elements of carbapenem-resistant Klebsiella pneumoniae causing infections in Chile

M. Veloso, J. Acosta, P. Arros, C. Berrios-Pasten, R. Rojas, M. Varas, M. L. Allende, F. P. Chavez, P. Araya, J. C. Hormazabal, R. Lagos, A. E. Marcoleta

This study analyzes ten carbapenem-resistant K. pneumoniae isolates from Chile, identifying resistance genes, plasmids, and virulence factors associated with antibiotic resistance and pathogenic potential.

bioRxiv · Nov 28, 2022 · PreprintMicrobiology

p53 restoration in small cell lung cancer identifies a latent Cyclophilin-dependent necrosis mechanism

J. Acosta, Q. Li, N. F. Freebrug, N. Murali, G. P. Grothusen, M. Cicchini, H. Mai, A. C. Gladstein, K. M. Adler, K. R. Doerig, J. Li, M. Ruiz-Torres, K. L. Manning, B. Stanger, L. Busino, , D. M. Feldser

This study shows that p53 restoration in SCLC can induce necrosis via cyclophilin-dependent mechanisms, revealing subtype-specific responses and potential therapeutic targets.

bioRxiv · Jul 22, 2022Cancer Biology