Author

K. M. Adler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. C. Gladstein· 2 shared D. M. Feldser· 2 shared K. R. Doerig· 2 shared A. A. Gudiel· 1 shared B. Stanger· 1 shared D. C. Wallace· 1 shared D. M. Walter· 1 shared G. P. Grothusen· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

A. C. Gladstein

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Setd2 inactivation sensitizes lung adenocarcinoma to inhibitors of oxidative respiration and mTORC1 signaling

D. M. Walter, A. C. Gladstein, K. R. Doerig, R. Natesan, S. G. Baskaran, A. A. Gudiel, K. M. Adler, J. O. Acosta, D. C. Wallace, I. A. Asangani, D. M. Feldser

This study shows that SETD2 inactivation in lung adenocarcinoma leads to increased oxidative metabolism and mTORC1 activity, making these tumors sensitive to inhibitors of oxidative respiration and mTORC1.

bioRxiv · Oct 6, 2022 · PreprintCancer Biology

p53 restoration in small cell lung cancer identifies a latent Cyclophilin-dependent necrosis mechanism

J. Acosta, Q. Li, N. F. Freebrug, N. Murali, G. P. Grothusen, M. Cicchini, H. Mai, A. C. Gladstein, K. M. Adler, K. R. Doerig, J. Li, M. Ruiz-Torres, K. L. Manning, B. Stanger, L. Busino, , D. M. Feldser

This study shows that p53 restoration in SCLC can induce necrosis via cyclophilin-dependent mechanisms, revealing subtype-specific responses and potential therapeutic targets.

bioRxiv · Jul 22, 2022Cancer Biology