Cancer BiologybioRxivPreprint
A Degenerate PCNA-Interacting Peptide (DPIP) box targets RNF168 to replicating DNA to limit 53BP1 signaling
Y. Yang, D. Jayaprakash, R. Hollingworth…·C. Vaziri
This study identifies a non-canonical role of RNF168 at DNA replication forks, showing it suppresses 53BP1 signaling through PCNA binding, independent of its canonical DSB response function.
DOI 10.1101/2021.03.17.435897