Author

K. Pearce

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Organism:Drosophila· 1

Frequent Co-Authors

A. Fradet-Turcotte· 1 shared A. Jablonski· 1 shared A. S. Mikheyev· 1 shared A.-M. Turner· 1 shared C. Vaziri· 1 shared D. Jayaprakash· 1 shared D. Margolis· 1 shared E. Mutter-Rottmayer· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperCancer Biology

A. Fradet-Turcotte

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3 papers

Recent·Most cited

Purging of highly deleterious alleles through an extreme bottleneck

O. P. Stuart, R. Cleave, K. Pearce, M. J. Magrath, A. S. Mikheyev

The paper analyzes genetic diversity in wild and captive-bred populations of the Lord Howe Island stick insect to test if extreme inbreeding following a population bottleneck purges deleterious alleles.

bioRxiv · Jul 23, 2024Evolutionary Biology

A Degenerate PCNA-Interacting Peptide (DPIP) box targets RNF168 to replicating DNA to limit 53BP1 signaling

Y. Yang, D. Jayaprakash, R. Hollingworth, S. Chen, A. Jablonski, E. Mutter-Rottmayer, Y. Gao, J. Anand Ramlal, J. An, X. Chen, K. Pearce, S.-A. Blanchet, A. Fradet-Turcotte, G. Stewart, C. Vaziri

This study identifies a non-canonical role of RNF168 at DNA replication forks, showing it suppresses 53BP1 signaling through PCNA binding, independent of its canonical DSB response function.

bioRxiv · Mar 17, 2021 · PreprintCancer Biology

Degradation of Polycomb Repressive Complex 2 with an EED-targeted Bivalent Chemical Degrader

F. Potjewyd, A.-M. Turner, J. Beri, J. Rectenwald, J. Norris-Drouin, S. Cholensky, D. Margolis, K. Pearce, L. Herring, L. I. James

This paper introduces a bivalent chemical degrader, UNC6852, that targets PRC2 components and demonstrates its ability to degrade PRC2 and inhibit EZH2 activity in cancer cells.

bioRxiv · Jun 21, 2019Cancer Biology