B1 SINE-binding ZFP266 impedes reprogramming through suppression of chromatin opening mediated by pioneering factors
D. F. Kaemena, M. Yoshihara, J. Ashmore, M. Beniazza, S. Zhao, M. Bertenstam, V. Olariu, S. Katayama, K. Okita, S. Tomlinson, K. Yusa, K. Kaji
This study identifies ZFP266 as a reprogramming roadblock gene that suppresses chromatin opening by binding SINEs near pioneer factor binding sites, and shows that replacing its KRAB domain with a co-activator domain enhances reprogramming.
bioRxiv · Jan 4, 2022 · PreprintCell Biology