M. Yoshihara

B1 SINE-binding ZFP266 impedes reprogramming through suppression of chromatin opening mediated by pioneering factors

This study identifies ZFP266 as a reprogramming roadblock gene that suppresses chromatin opening by binding SINEs near pioneer factor binding sites, and shows that replacing its KRAB domain with a co-activator domain enhances reprogramming.

Transient DUX4 expression induces blastomere-like expression program that is marked by SLC34A2

The paper shows that transient DUX4 expression in hESCs generates iBM cells with EGA-like profiles, resembling 8-cell blastomeres and can be enriched using SLC34A2.

Ectopic histone clipping in the mouse model of progressive myoclonus epilepsy

This study identifies CSTB as a regulator of histone H3 tail clipping in NPCs and links its deficiency to epigenetic dysregulation and impaired mitochondrial function in a mouse model of progressive myoclonus epilepsy.

Balancing Selection at HLA-G Modulates Fetal Survival, Preeclampsia and Human Birth Sex Ratio

The paper investigates the role of HLA-G genetic variation in fetal survival, preeclampsia, and human sex ratio, finding balancing selection influences these outcomes.

Single cell map of the human ovarian cortex.

This study maps the single-cell transcriptome and surface antigens of ovarian cortex cells, revealing six main cell types and showing DDX4 captures perivascular cells, not oogonial stem cells, supporting a limited ovarian reserve.