Author

K. Okita

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 2 Pathology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:chromatin & epigenetic regulation· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

D. F. Kaemena· 1 shared H. Ito· 1 shared H. Sakurai· 1 shared J. Ashmore· 1 shared J. He· 1 shared K. Hasegawa· 1 shared K. Kaji· 1 shared K. Yusa· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCell Biology

D. F. Kaemena

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Hit-and-run silencing of endogenous DUX4 by targeting DNA hypomethylation on D4Z4 repeats in facioscapulohumeral muscular dystrophy

M. Sasaki-Honda, T. Jonouchi, M. Arai, J. He, K. Okita, S. Sakurai, T. Yamamoto, H. Sakurai

This study uses hit-and-run silencing to suppress DUX4 in FSHD patient-derived iPSCs by targeting DNA hypomethylation on D4Z4 repeats, achieving sustained suppression for at least two weeks.

bioRxiv · Apr 12, 2022 · PreprintPathology

B1 SINE-binding ZFP266 impedes reprogramming through suppression of chromatin opening mediated by pioneering factors

D. F. Kaemena, M. Yoshihara, J. Ashmore, M. Beniazza, S. Zhao, M. Bertenstam, V. Olariu, S. Katayama, K. Okita, S. Tomlinson, K. Yusa, K. Kaji

This study identifies ZFP266 as a reprogramming roadblock gene that suppresses chromatin opening by binding SINEs near pioneer factor binding sites, and shows that replacing its KRAB domain with a co-activator domain enhances reprogramming.

bioRxiv · Jan 4, 2022 · PreprintCell Biology

Generation of iPSCs from endangered Grevy's zebra and comparative transcriptomic analysis of mammalian PSCs

Y. Endo, K.-i. Kamei, K. Hasegawa, K. Okita, H. Ito, S. Terada, M. Inoue-Murayama

This study generates iPSCs from Grevy's zebra and compares their transcriptome to other mammalian PSCs, revealing evolutionary conservation and species-specific variation in pluripotency genes.

bioRxiv · Aug 10, 2021 · PreprintCell Biology