Early life tolerance depends on a subset of specialized dendritic cells and is reinforced by the skin microbiota
A. A. Weckel, M. O. Dhariwala, K. Ly, O. T. Ojewumi, J. B. Riggs, J. R. Gonzalez, L. R. Dwyer, J. N. Okoro, J. M. Leech, M. S. Bacino, G. D. Cho, G. merana, N. Anandasabapathy, Y. O. Kumamoto, T. C. Scharschmidt
The paper identifies CD301b+ dendritic cells in neonatal skin that promote tolerance to commensal bacteria through regulatory T cell generation, reinforced by microbial interactions.
bioRxiv · Jun 23, 2022 · PreprintImmunology