L. J. Berg

Optimized detection of acute MHV68 infection with a reporter system identifies large peritoneal macrophages as a dominant target of primary infection

This study uses a beta-lactamase reporter system with flow cytometry to identify MHV68-infected cells in mice, revealing large peritoneal macrophages as primary targets and dynamic changes in immune cell populations during infection.

The Tec kinase ITK differentially optimizes NFAT, NF-κB, and MAPK signaling during early T cell activation to regulate graded gene induction

This study shows ITK differentially optimizes NFAT, NF-κB, and MAPK signaling during T cell activation, leading to graded gene induction based on TCR signal strength.