E. T. Clambey

Divergent Outcomes Of Myeloid Cell Infection By Gammaherpesvirus 68 Reveal Stepwise Regulation By Host And Viral Factors

This study shows that myeloid cells infected by gammaherpesvirus 68 exhibit divergent outcomes regulated by viral and host factors, with IL-4 converting restricted infection to productive replication.

Novel EGFR-Mutant Mouse Models of Lung Adenocarcinoma Reveal Adaptive Immunity Requirement for Durable Osimertinib Response

Gammaherpesvirus ncRNAs share conserved features of binding and virulence despite lack of sequence conservation

This study shows that divergent gammaherpesvirus non-coding RNAs share conserved interactions with host RBPs and contribute to disease despite lacking sequence conservation.

Immune Checkpoint Activity Regulates Polycystic Kidney Disease Progression

This study investigates immune checkpoint activity in ADPKD, finding that dual checkpoint inhibition improves disease outcomes in adult-onset models.

Adaptive immunity is required for durable responses to alectinib in murine models of EML4-ALK lung cancer

This paper shows that adaptive immunity enhances the durability of alectinib response in EML4-ALK lung cancer models, with CD8+ T cells playing a key role.

Lytic infection with murine gammaherpesvirus 68 activates host and viral RNA polymerase III-dependent promoters to enhance non-coding RNA expression

This study shows that gammaherpesvirus 68 infection increases host and viral RNA polymerase III promoter activity, leading to enhanced non-coding RNA expression.

NPEPPS is a novel and druggable driver of platinum resistance

This study identifies NPEPPS as a driver of cisplatin resistance in bladder cancer and shows its inhibition can enhance cisplatin efficacy in preclinical models.

Cancer cell-specific MHCII expression as a determinant of the immune infiltrate organization and function in the non-small cell lung cancer tumor microenvironment

The paper examines MHCII expression in NSCLC tumor microenvironment and finds it correlates with immune infiltration, spatial proximity, and improved survival.

Optimized detection of acute MHV68 infection with a reporter system identifies large peritoneal macrophages as a dominant target of primary infection

This study uses a beta-lactamase reporter system with flow cytometry to identify MHV68-infected cells in mice, revealing large peritoneal macrophages as primary targets and dynamic changes in immune cell populations during infection.

Redefining De Novo Gammaherpesvirus Infection Through High-Dimensional, Single-Cell Analysis of Virus and Host

This paper uses single-cell RNA sequencing and mass cytometry to analyze variation in viral and host gene expression during de novo gammaherpesvirus infection.

Cancer Cell Intrinsic Expression of MHCII Regulates the Immune Microenvironment and Response to Anti-PD-1 Therapy in Lung Adenocarcinoma

This study shows that cancer cell expression of MHCII affects T cell infiltration and response to anti-PD-1 therapy in lung adenocarcinoma.

The gammaherpesvirus 68 viral cyclin facilitates reactivation by promoting latent gene expression.

This study shows that the gammaherpesvirus 68 viral cyclin promotes reactivation by enhancing latent gene expression, revealing distinct stages of latency.

Multidimensional analysis of Gammaherpesvirus RNA expression reveals unexpected heterogeneity of gene expression

This paper uses single-cell analysis to reveal heterogeneity in gammaherpesvirus gene expression across different infection stages.

High-dimensional characterization of IL-10 production and IL-10 dependent regulation during primary gammaherpesvirus infection

This paper investigates IL-10 production and its regulatory role during primary gammaherpesvirus infection using high-dimensional analysis in mice.

Tumor-Intrinsic Response to IFNgamma Shapes the Tumor Microenvironment and Anti-PD-1 Response in NSCLC

This study identifies tumor-intrinsic IFN-gamma signaling as a determinant of anti-PD-1 response in NSCLC by altering the tumor microenvironment.