Inclusion of glycopeptides in hydrogen/deuterium exchange mass spectrometry analysis of SARS-CoV-2 spike ectodomain provides increased sequence coverage
C. A. Haynes, T. R. Keppel, B. Mekonnen, S. H. Osman, Y. Zhou, A. R. Woolfitt, J. Baudys, J. R. Barr, D. Wang
This study shows that including glycopeptides in HDX-MS analysis of SARS-CoV-2 spike protein increases sequence coverage and improves confidence in structural dynamics analysis.
bioRxiv · Jun 14, 2023 · PreprintBiochemistry