Author

D. E. Wentworth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 9 Evolutionary Biology· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 10 Approach:experimental assay· 8 Approach:statistical model· 5 Organism:human· 4 Organism:mouse· 4 Assay:proteomics· 3 Assay:whole-genome sequencing· 3 Assay:metagenomics· 2

Frequent Co-Authors

B. Zhou· 6 shared J. R. Barnes· 5 shared D. Cui· 3 shared J. Hossain· 3 shared L. Wang· 3 shared M. Wilson· 3 shared N. Jiang· 3 shared X. Fan· 3 shared

Activity by Year

2018-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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6 shared papersMicrobiology

B. Zhou

Mutual co-authors in cluster

Author profile →

13 papers

Recent·Most cited

Delay of innate immune responses following influenza B virus infection affects the development of robust antibody response in ferrets

T. Rowe, A. Fletcher, R. A. Richardson, M. Lange, G. A. Sautto, G. A. Kirchenbaum, Y. Hatta, G. Jasso, D. E. Wentworth, T. M. Ross

This study shows that delayed innate immune responses to influenza B virus in ferrets lead to weaker antibody responses compared to influenza A virus.

mBio · Feb 5, 2025Peer-reviewedMicrobiology

Imprinted anti-hemagglutinin and anti-neuraminidase antibody responses after childhood infections of A(H1N1) and A(H1N1)pdm09 influenza viruses

P. Daulagala, B. Mann, K. Leung, E. Lau, L. Yung, R. Lei, S. I. N. Nizami, J. T. Wu, S. S. Chiu, R. S. Daniels, N. C. Wu, D. E. Wentworth, J. S. M. Peiris, H.-L. Yen

The paper characterizes anti-HA and anti-NA antibody responses to A(H1N1) and A(H1N1)pdm09 influenza viruses in individuals born between 1950-2015, finding age-dependent imprinting and cross-reactivity to multiple antigenic variants.

bioRxiv · Feb 1, 2023Microbiology

Bivalent mRNA vaccine improves antibody-mediated neutralization of many SARS-CoV-2 Omicron lineage variants

N. Jiang, L. Wang, M. Hatta, C. Feng, M. Currier, X. Lin, J. Hossain, D. Cui, B. R. Mann, N. A. Kovacs, W. Wang, G. Atteberry, M. Wilson, R. Chau, K. A. Lacek, , B. Zhou

This study evaluates the neutralizing antibody response to bivalent mRNA vaccines against multiple Omicron variants, showing enhanced neutralization against BQ.1 and BQ.1.1.

bioRxiv · Jan 8, 2023 · PreprintMicrobiology

Cross-neutralization and viral fitness of SARS-CoV-2 Omicron sublineages

H. Xia, J. Yeung, B. Kalveram, C. J. Bills, J. Y.-C. Chen, C. Kurhade, j. Zou, S. G. Widen, B. R. Mann, R. J. Kondor, T. C. Davis, B. Zhou, D. E. Wentworth, X. Xie, P.-Y. Shi

This study examines the replication and cross-neutralization of SARS-CoV-2 Omicron sublineages in mice and human airway cultures, finding distinct antigenic profiles and bivalent vaccine support.

bioRxiv · Nov 8, 2022Microbiology

Evolutionary features of a prolific subtype of avian influenza A virus in European waterfowl

M. Wille, C. Tolf, N. Latorre-Margalef, R. A. M. Fouchier, R. A. Halpin, D. E. Wentworth, J. Ragwani, O. G. Pybus, B. Olsen, J. Waldenstrom

This study investigates the evolutionary dynamics of avian influenza A virus in waterfowl, finding lineage replacement and reassortment across multiple viral segments over time.

bioRxiv · Nov 24, 2021Evolutionary Biology

N-glycosylation profiles of the SARS-CoV-2 spike D614G mutant and its ancestral protein characterized by advanced mass spectrometry

D. Wang, B. Zhou, T. Keppel, M. Solano, J. Baudys, J. Goldstein, M. G. Finn, X. Fan, A. P. Chapman, J. Bundy, A. R. Woolfitt, S. Osman, J. L. Pirkle, D. E. Wentworth, J. R. Barr

This study compares N-glycosylation profiles of SARS-CoV-2 spike proteins with D614G mutation and ancestral form using mass spectrometry, finding changes in glycan distribution and complexity.

bioRxiv · Jul 26, 2021Biochemistry

Identification of novel human derived influenza viruses in pigs with zoonotic potential.

r. tapia, B. Brito, M. Saavedra, j. mena, T. Garcia-Salum, R. Rathnasinghe, G. Barriga, K. Tapia, V. Garcia, S. Bucarey, Y. Jang, D. E. Wentworth, M. Torremorell, V. Neira-Ramirez, R. A. Medina

The paper identifies novel human-derived influenza viruses in Chilean pigs, showing zoonotic potential and antigenic drift.

bioRxiv · Jun 8, 2021 · PreprintMicrobiology

SARS-CoV-2 susceptibility of cell lines and substrates commonly used in diagnosis and isolation of influenza and other viruses

L. Wang, X. Fan, G. Bonenfant, D. Cui, J. Hossain, N. Jiang, G. Larson, M. Currier, J. Liddell, M. Wilson, A. Tamin, J. Harcourt, J. Ciomperlik-Patton, H. Pang, N. Dybdahl-Sissoko, , B. Zhou

This study evaluates SARS-CoV-2 susceptibility in cell lines used for influenza and other virus diagnosis, finding that some are permissive while others are not, with MDCK cells being insusceptible due to low ACE2 expression.

bioRxiv · Jan 4, 2021Microbiology

SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility

B. Zhou, T. T. N. Thao, D. Hoffmann, A. Taddeo, N. Ebert, F. Labroussaa, A. Pohlmann, J. King, J. Portmann, N. J. Halwe, L. Ulrich, B. S. Trueb, J. N. Kelly, X. Fan, B. Hoffmann, , M. Beer

This study shows the SARS-CoV-2 D614G variant has enhanced replication and transmissibility in animal models, explaining its global dominance.

bioRxiv · Oct 27, 2020Microbiology

Rapid Development of Neutralizing and Diagnostic SARS-COV-2 Mouse Monoclonal Antibodies

A. P. Chapman, X. Tang, J. R. Lee, A. Chida, K. Mercer, R. E. Wharton, M. H. Kainulainen, J. L. Harcourt, R. B. Martines, M. Schroeder, L. Zhao, A. Bryksin, B. Zhou, E. Bergeron, B. C. Bollweg, , J. M. Goldstein

This study develops and characterizes high-affinity mouse monoclonal antibodies against SARS-CoV-2, showing their neutralizing and diagnostic potential.

bioRxiv · Oct 13, 2020Immunology

Integrating genotypes and phenotypes improves long-term forecasts of seasonal influenza A/H3N2 evolution

J. Huddleston, J. R. Barnes, T. Rowe, R. Kondor, D. E. Wentworth, L. Whittaker, B. Ermetal, R. S. Daniels, J. W. McCauley, S. Fujisaki, K. Nakamura, N. Kishida, S. Watanabe, H. Hasegawa, I. Barr, , T. Bedford

This study develops a forecasting framework for influenza A/H3N2 evolution by integrating phenotypic antigenic drift data with sequence-based fitness estimates, showing improved long-term predictions.

bioRxiv · Jun 12, 2020Evolutionary Biology

Mitigating Pandemic Risk with Influenza A Virus Field Surveillance at a Swine-Human Interface

B. L. Rambo-Martin, M. W. Keller, M. M. Wilson, J. M. Nolting, T. K. Anderson, A. L. Vincent, U. Bagal, Y. Jang, E. B. Neuhaus, C. T. Davis, A. S. Bowman, D. E. Wentworth, J. R. Barnes

The paper describes using field-derived nanopore sequencing to identify a novel swine influenza A virus that posed a pandemic risk, leading to the development of a vaccine candidate and real-time public health response.

bioRxiv · Mar 21, 2019 · PreprintMicrobiology

Avian influenza viruses in wild birds: virus evolution in a multi-host ecosystem

D. Venkatesh, M. J. Poen, T. M. Bestebroer, R. D. Scheuer, O. Vuong, M. Chkhaidze, A. Machablishvili, J. Mamuchadze, L. Ninua, N. B. Fedorova, R. A. Halpin, X. Lin, A. Ransier, T. B. Stockwell, D. E. Wentworth, , N. S. Lewis

This study tracks avian influenza virus evolution in wild birds across three migratory flyways in Georgia, revealing subtype diversity, reassortment patterns, and genetic relationships with global AIV populations.

bioRxiv · Mar 17, 2018Microbiology