Mechanistic insights into global suppressors of protein folding defects
G. Chattopadhyay, J. Bhowmick, K. Manjunath, S. Ahmed, P. Goyal, R. Varadarajan
The paper identifies global suppressor mutations that rescue protein folding defects and shows they stabilize proteins through refolding rate acceleration, with some providing structural insights.
bioRxiv · Nov 18, 2021Biophysics