Author

G. Chattopadhyay

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:protein folding & dynamics· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

R. Varadarajan· 3 shared S. Ahmed· 3 shared K. Manjunath· 2 shared A. Ashok· 1 shared A. S. Rosenberg· 1 shared A. W. T. Chiang· 1 shared B. G. Voldborg· 1 shared B. P. Kellman· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersBiophysics

R. Varadarajan

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Author profile →

4 papers

Recent·Most cited

Ter-Seq: A high-throughput method to stabilize transient ternary complexes and measure associated kinetics

G. Chattopadhyay, S. Ahmed, N. S. Srilatha, A. Ashok, R. Varadarajan

The paper introduces Ter-Seq, a method to stabilize ternary complexes and measure kinetics using CcdA-CcdB-GyrA14 as a model, identifying mutations that affect complex formation and rejuvenation rates.

bioRxiv · May 18, 2022Biophysics

Mechanistic insights into global suppressors of protein folding defects

G. Chattopadhyay, J. Bhowmick, K. Manjunath, S. Ahmed, P. Goyal, R. Varadarajan

The paper identifies global suppressor mutations that rescue protein folding defects and shows they stabilize proteins through refolding rate acceleration, with some providing structural insights.

bioRxiv · Nov 18, 2021Biophysics

Stabilizing proteins through saturation suppressor mutagenesis.

S. Ahmed, K. Manjunath, G. Chattopadhyay, R. Varadarajan

This paper introduces a method to identify stabilizing protein mutations by screening libraries with destabilizing mutations, demonstrating its effectiveness in enhancing protein stability.

bioRxiv · Aug 7, 2021Biophysics

Combating viral contaminants in CHO cells by engineering STAT1 mediated innate immunity

A. W. T. Chiang, S. Li, B. P. Kellman, G. Chattopadhyay, Y. Zhang, C.-C. Kuo, J. M. Gutierrez, F. Ghazi, H. Schmeisser, P. Menard, S. Petersen Bjorn, B. G. Voldborg, A. S. Rosenberg, M. Puig, N. E. Lewis

The paper identifies Gfi1 and Trim24 as repressors of STAT1 in CHO cells and shows that knocking them out increases resistance to RNA viruses.

bioRxiv · Sep 21, 2018Bioengineering