The Reelin Receptor ApoER2 is a Cargo for the Adaptor Protein Complex AP-4: Implications for Hereditary Spastic Paraplegia.
M. Caracci, H. Pizarro, C. Alarcon-Godoy, L. M. Fuentealba, P. Farfan, R. De Pace, N. Santibanez, V. A. Cavieres, T. Pastor, J. Bonifacino, G. Mardones, M.-P. Marzolo
This study identifies ApoER2 as a cargo of the AP-4 complex and shows that AP-4 defects affect its trafficking and Reelin signaling, potentially contributing to Hereditary Spastic Paraplegia.
bioRxiv · Dec 21, 2023Cell Biology