Author

J. Brezovsky

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 4 Approach:experimental assay· 3 Assay:protein structure· 3 Approach:statistical model· 3 Approach:mechanistic / dynamical model· 2 Organism:Arabidopsis· 1 Organism:bacteria (other)· 1 Approach:comparative / phylogenetic analysis· 1

Frequent Co-Authors

B. Surpeta· 3 shared A. Palyzova· 2 shared D. K. Sarkar· 2 shared H. Maresova· 2 shared M. Grulich· 2 shared A. Bailly· 1 shared A. Pawela· 1 shared C. Sequeiros-Borja· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersBiochemistry

B. Surpeta

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Incorporating prior knowledge to seeds of adaptive sampling molecular dynamics simulations of ligand transport in enzymes with buried active sites

D. K. Sarkar, B. Surpeta, J. Brezovsky

The paper integrates prior knowledge into initial seeds for adaptive sampling simulations to better model ligand transport in enzymes with buried active sites, improving consistency and predictive accuracy.

bioRxiv · Sep 21, 2023 · PreprintBiophysics

Engineering dynamic gates in binding pocket of penicillin G acylase to selectively degrade bacterial signaling molecules

M. Grulich, B. Surpeta, A. Palyzova, H. Maresova, J. Zahradnik, J. Brezovsky

This paper designs engineered variants of penicillin G acylase to selectively degrade bacterial signaling molecules, showing significant shifts in substrate specificity.

bioRxiv · May 9, 2023 · PreprintBiochemistry

Nano-structured Hydrotrope-Caged Cytochrome c with Boosted Stability in Harsh Environments: A Molecular Insight

P. Bharadwaj, D. K. Sarkar, M. Bisht, S. M. Shet, S. K. Nataraj, V. Lokesh, G. Franklin, J. Brezovsky, D. Mondal

This study demonstrates that ATP and [Cho][Sal] ionic liquid form nano-structures that stabilize Cytochrome c, enhancing its peroxidase activity and thermal tolerance under harsh conditions.

bioRxiv · Feb 5, 2023Biochemistry

Restriction of access to the central cavity is a major contributor to substrate selectivity in plant ABCG transporters

K. Pakuła, C. Sequeiros-Borja, W. Biała-Leonhard, A. Pawela, J. Banasiak, A. Bailly, M. Radom, M. Geisler, J. Brezovsky, M. Jasinski

The paper identifies a narrow access path in MtABCG46 that contributes to substrate selectivity in plant ABCG transporters.

bioRxiv · Aug 16, 2022Biochemistry

Common Dynamic Determinants Govern Quorum Quenching Activity in N-terminal Serine Hydrolases

B. Surpeta, M. Grulich, A. Palyzova, H. Maresova, J. Brezovsky

This study identifies common dynamic determinants governing quorum quenching activity in N-terminal serine hydrolases through simulations and experimental validation.

bioRxiv · Jan 13, 2022Biochemistry