Author

J. C. Doyle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Approach:deep learning· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:diffusion model· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

B. C. Bastian· 1 shared B. S. Taylor· 1 shared C. M. Blakely· 1 shared C. S. Henry· 1 shared F. Xiao· 1 shared J. S. Li· 1 shared L. Lin· 1 shared M. A. Gubens· 1 shared

Activity by Year

2016-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperCancer Biology

B. C. Bastian

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Author profile →

3 papers

Recent·Most cited

Flux exponent control predicts metabolic dynamics from network structure

F. Xiao, J. S. Li, J. C. Doyle

This paper introduces flux exponent control (FEC), a constraint-based method to model dynamic metabolic fluxes from network structure, demonstrating its application to glycolysis dynamics.

bioRxiv · Mar 23, 2023 · PreprintBioengineering

Metabolic multi-stability and hysteresis in a model aerobe-anaerobe microbiome community

T. Khazaei, R. L. Williams, S. R. Bogatyrev, J. C. Doyle, C. S. Henry, R. F. Ismagilov

The paper shows that multi-stability and hysteresis explain shifts to and persistence of aerobe-anaerobe microbiome states under changing oxygen and nutrient conditions.

bioRxiv · Feb 28, 2020Ecology

Novel computational method for predicting polytherapy switching strategies to overcome tumor heterogeneity and evolution

V. D. Jonsson, C. M. Blakely, L. Lin, S. Asthana, V. Olivas, M. A. Gubens, N. Matni, B. C. Bastian, B. S. Taylor, J. C. Doyle, T. G. Bivona

This paper develops a computational framework to predict dynamic polytherapy switching strategies to address tumor heterogeneity and evolution in lung adenocarcinoma.

bioRxiv · Nov 8, 2016Cancer Biology