S. Asthana

Oxysterol accumulation in aging cells alters GPCR signalling

This study shows that oxysterol accumulation in aged cells disrupts CXCR4 signaling by altering G-protein coupling specificity.

SARS-CoV-2 spike antibodies cross-react with dengue virus and enhance infection in vitro and in vivo

The paper shows that SARS-CoV-2 spike antibodies can enhance DENV2 infection in vitro and in vivo, suggesting potential for increased dengue severity in COVID-19 survivors.

Conformational dynamics of a nicotinic receptor neurotransmitter site

The paper uses molecular dynamics simulations to study conformational changes in a nicotinic receptor site induced by agonists, identifying key steps in the low-to-high affinity transition.

Detergent induced structural perturbations in peanut agglutinin: Insights from spectroscopic and molecular dynamic simulation studies

This study investigates how SDS and CTAB detergents affect the structure of peanut agglutinin using spectroscopic and molecular dynamics simulations, revealing structural perturbations and conformational changes.

Modulated protein-sterol interactions drive oxysterol-induced impaired CXCR4 signalling

This study investigates how oxysterols impair CXCR4 signaling by disrupting cholesterol-protein interactions and altering signaling residue conformations.

RNA-protein interactome at the Hepatitis E virus internal ribosome entry site

This study identifies the RNA-protein interactome of the Hepatitis E virus IRESl element and confirms its function as a bona fide internal ribosome entry site.

A Pan-Cancer Census of Dominant Tumor Immune Archetypes

The paper identifies dominant immune system archetypes across 364 tumors from 12 cancer types using flow cytometry and transcriptomic data, linking them to tumor biology classifications.

Immunological and cardio-vascular pathologies associated with SARS-CoV-2 infection in golden syrian hamster

This study shows that SARS-CoV-2 infection in golden Syrian hamsters causes lung and cardiovascular pathologies similar to human COVID-19, suggesting GSH as a model for studying long-term effects.

Japanese encephalitis virus capsid protein interacts with non-lipidated MAP1LC3 on replication membranes and lipid droplets

This paper identifies a direct interaction between JEV capsid protein and non-lipidated MAP1LC3 on replication membranes and lipid droplets, independent of p62/SQSTM1.

Synthetic essentiality of metabolic regulator PDHK1 in PTEN-deficient cells and cancers

The paper identifies PDHK1 as a synthetic-essential gene in PTEN-deficient cells and cancers, showing its upregulation drives aerobic glycolysis and correlates with poor patient survival.

Novel computational method for predicting polytherapy switching strategies to overcome tumor heterogeneity and evolution

This paper develops a computational framework to predict dynamic polytherapy switching strategies to address tumor heterogeneity and evolution in lung adenocarcinoma.