Author

J. C. Halpin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

A. E. Keating· 1 shared A. Singer· 1 shared B. Huang· 1 shared D. Whitney· 1 shared F. Rigoldi· 1 shared J. L. M. Kotler· 1 shared S. Wang· 1 shared T. O. Street· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiochemistry

A. E. Keating

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2 papers

Recent·Most cited

Molecular determinants of TRAF6 binding specificity suggest that native interaction partners are not optimized for affinity

J. C. Halpin, D. Whitney, F. Rigoldi, V. Sivaraman, A. Singer, A. E. Keating

The paper identifies TRAF6 MATH domain binding preferences using combinatorial peptide libraries and structural modeling, revealing that native ligands are not optimized for affinity.

bioRxiv · May 8, 2022Biochemistry

The ER chaperones BiP and Grp94 regulate the formation of insulin-like growth factor 2 (IGF2) oligomers

Y. Jin, J. L. M. Kotler, S. Wang, B. Huang, J. C. Halpin, T. O. Street

This study shows that ER chaperones BiP and Grp94 regulate proIGF2 folding and oligomerization, with BiP suppressing and Grp94 enhancing oligomerization under different ATP/ADP conditions.

bioRxiv · Sep 24, 2020Biochemistry