Author

J. C. McCoy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:structural biology· 1

Frequent Co-Authors

M. Czepnik· 2 shared M. Hyvonen· 2 shared A. Hagg· 1 shared C. A. Harrison· 1 shared G. Fischer· 1 shared K. L. Walton· 1 shared M. J. Mills· 1 shared P. Gregorevic· 1 shared

Activity by Year

2017-2017 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersBiochemistry

M. Czepnik

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2 papers

Recent·Most cited

Molecular characterization of latent GDF8 reveals mechanisms of activation

R. G. Walker, J. C. McCoy, M. Czepnik, M. J. Mills, A. Hagg, K. L. Walton, T. Cotton, M. Hyvonen, R. T. Lee, P. Gregorevic, C. A. Harrison, T. Thompson

This study characterizes the latent and activated states of GDF8 using structural and mutagenesis analyses, revealing that latent GDF8 is spring-loaded and can be activated without proteolytic cleavage.

bioRxiv · Aug 17, 2017Biochemistry

Structure of the human pro-myostatin precursor and determinants of growth factor latency

T. R. Cotton, G. Fischer, X. Wang, J. C. McCoy, M. Czepnik, T. B. Thompson, M. Hyvonen

This study determines the structure of human pro-myostatin and identifies features responsible for its latent state, offering insights into myostatin activation and potential inhibitor design.

bioRxiv · Jul 28, 2017Biochemistry