M. Hyvonen

A Recombinant Approach For Stapled Peptide Discovery YieldsInhibitors of the RAD51 Recombinase

This paper describes a recombinant approach for stapled peptide discovery and evaluates its effectiveness as inhibitors of the RAD51 recombinase.

Microfluidics-enabled fluorescence-activated cell sorting of single pathogen-specific antibody secreting cells for the rapid discovery of monoclonal antibodies

This paper presents a microfluidics-based method to rapidly discover monoclonal antibodies from antigen-specific antibody secreting cells, achieving high-affinity and neutralizing antibodies against SARS-CoV-2.

Functional metagenomic screening in microfluidic droplets identifies a β-glucuronidase in an unprecedented sequence neighbourhood

This study identifies a novel β-glucuronidase from a metagenomic library using microfluidic droplet screening, revealing a new GH3 family member with unique functional and structural properties.

Divergent binding mode for a protozoan BRC repeat to RAD51

The paper investigates the binding of two BRC repeats from Leishmania infantum BRCA2 to RAD51, revealing distinct binding modes and affinities compared to human BRC4.

Consensus tandem tetratricopeptide repeat proteins are complex superhelical nanosprings

This study investigates the mechanical properties of consensus-designed tetratricopeptide repeats (CTPRs) using single-molecule techniques, revealing their spring-like behavior and superhelical structure.

A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death

The paper identifies CAM833, a small-molecule inhibitor of BRCA2-RAD51 interaction, which disrupts RAD51 assembly and enhances DNA damage-induced cell death in BRCA2-wildtype cells.

Improved RAD51 binders through motif shuffling based on the modularity of BRC repeats

The paper creates and tests chimeric BRC repeats to improve RAD51 binding, finding that shuffled modules can enhance binding affinity and function in human cells.

Rapid Alkalinization Factor (RALF) gene family genomic structure and transcriptional regulation during host-pathogen crosstalk in Fragaria vesca and Fragariax ananassa strawberry

The paper characterizes the RALF gene family in strawberry species, identifying genomic structure and transcriptional regulation during host-pathogen interactions.

Molecular characterization of latent GDF8 reveals mechanisms of activation

This study characterizes the latent and activated states of GDF8 using structural and mutagenesis analyses, revealing that latent GDF8 is spring-loaded and can be activated without proteolytic cleavage.

Structure of the human pro-myostatin precursor and determinants of growth factor latency

This study determines the structure of human pro-myostatin and identifies features responsible for its latent state, offering insights into myostatin activation and potential inhibitor design.