P. Gregorevic

Pantothenate Kinase 4 controls efficient skeletal muscle energy substrate metabolism via acetyl-CoA

This study identifies PanK4 as a regulator of skeletal muscle energy metabolism, showing its role in acetyl-CoA regulation and metabolic flexibility.

Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and regeneration.

This study identifies Zfp697 as a regulator of muscle regeneration and inflammation by mediating interferon gamma signaling and interacting with ncRNAs like miR-206.

Class IIa HDACs inhibit cell death pathways and protect muscle integrity in response to lipotoxicity

This study shows that HDAC4 and HDAC5 inhibit cell death pathways and protect muscle integrity by reducing oxidative metabolism and promoting survival under lipotoxic stress.

Loss of the Long Non-coding RNA OIP5-AS1 Exacerbates Heart Failure in a Sex-Specific Manner

This study shows that loss of OIP5-AS1 worsens heart failure in female mice but not males, suggesting a sex-specific role in cardiac function.

Integrated glycoproteomics identifies a role of N-glycosylation and galectin-1 on myogenesis and muscle development

The paper identifies N-glycosylation and galectin-1 as key regulators of myogenesis and muscle development through integrated glycoproteomics and functional studies.

Mechanisms involved in follistatin-induced hypertrophy and increased insulin action in skeletal muscle

This study shows that follistatin overexpression in muscle improves insulin-stimulated glucose uptake and protein synthesis, and that circulating follistatin increases after bariatric surgery, suggesting its role in insulin sensitivity.

Molecular characterization of latent GDF8 reveals mechanisms of activation

This study characterizes the latent and activated states of GDF8 using structural and mutagenesis analyses, revealing that latent GDF8 is spring-loaded and can be activated without proteolytic cleavage.