Brequinar and Dipyridamole in Combination Exhibits Synergistic Antiviral Activity Against SARS-CoV-2 in vitro: Rationale for a host-acting antiviral treatment strategy for COVID-19
J. F. Demarest, M. Kienle, R. Boytz, M. Ayres, E. Kim, D. Chung, V. Gandhi, R. A. Davey, D. B. Sykes, N. Shohdy, J. C. Pottage, V. S. Kumar
This study shows that combining brequinar and dipyridamole synergistically inhibits SARS-CoV-2 replication in vitro by depleting cellular pyrimidine nucleotides.
bioRxiv · Mar 30, 2022Microbiology