Author

R. A. Davey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 4 Approach:deep learning· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Approach:machine learning (classical)· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

C. F. Basler· 3 shared M. Anantpadma· 3 shared R. Boytz· 3 shared C. J. Donahue· 2 shared D. W. Leung· 2 shared G. K. Amarasinghe· 2 shared H. Mori· 2 shared J. J. Patten· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

C. F. Basler

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Single-cell image-based genetic screens systematically identify regulators of Ebola virus subcellular infection dynamics

R. J. Carlson, J. J. Patten, G. Stefanakis, B. Y. Soong, A. Radhakrishnan, A. Singh, N. Thakur, G. K. Amarasinghe, N. Hacohen, C. F. Basler, D. Leung, C. Uhler, R. A. Davey, P. C. Blainey

This study uses single-cell image-based CRISPR screens to identify host factors regulating Ebola virus infection, revealing new therapeutic targets like UQCRB and STRAP.

bioRxiv · Apr 6, 2024 · PreprintMicrobiology

The Role of Ebola Virus VP24 Nuclear Trafficking Signals in Infectious Particle Production

O. A. Vogel, E. Nafziger, A. Sharma, H. A. Pasolli, R. A. Davey, C. F. Basler

This study demonstrates that Ebola virus VP24 undergoes nuclear trafficking via IMPA and its nuclear export signal (NES) is critical for nucleocapsid formation and infectivity.

bioRxiv · Mar 13, 2024 · PreprintMicrobiology

Design of universal Ebola virus vaccine candidates via immunofocusing

D. Xu, A. E. Powell, A. Utz, M. Sanyal, J. Do, J. J. Patten, J. I. Moliva, N. J. Sullivan, R. A. Davey, P. S. Kim

This paper designs universal Ebola virus vaccine candidates using hyperglycosylation to focus antibody responses on conserved epitopes, showing cross-neutralizing activity against multiple orthoebolavirus species.

bioRxiv · Oct 14, 2023 · PreprintImmunology

CAPG is required for Ebola virus infection by controlling virus egress from infected cells.

H. Mori, J. M. Connell, C. J. Donahue, R. Boytz, J. Patten, D. W. Leung, D. J. Lacount, R. A. Davey

This study identifies CAPG as a host factor required for Ebola virus infection by stabilizing actin filaments and facilitating viral egress from infected cells.

bioRxiv · Apr 10, 2022Microbiology

Brequinar and Dipyridamole in Combination Exhibits Synergistic Antiviral Activity Against SARS-CoV-2 in vitro: Rationale for a host-acting antiviral treatment strategy for COVID-19

J. F. Demarest, M. Kienle, R. Boytz, M. Ayres, E. Kim, D. Chung, V. Gandhi, R. A. Davey, D. B. Sykes, N. Shohdy, J. C. Pottage, V. S. Kumar

This study shows that combining brequinar and dipyridamole synergistically inhibits SARS-CoV-2 replication in vitro by depleting cellular pyrimidine nucleotides.

bioRxiv · Mar 30, 2022Microbiology

Identification of druggable host targets needed for SARS-CoV-2 infection by combined pharmacological evaluation and cellular network directed prioritization both in vitro and in vivo.

J. Patten, P. T. Keiser, D. M. Gysi, G. Menichetti, H. Mori, C. J. Donahue, X. Gan, I. F. do Valle, K. Geoghegan-Barek, M. Anantpadma, R. Boytz, J. L. Berrigan, S. Hulsey-Stubbs, K. T. Ayazika, C. O'Leary, , R. A. Davey

The paper identifies 389 small molecules and 813 host targets that inhibit SARS-CoV-2 infection through in vitro and in vivo testing, using computational integration of drug activity and cellular networks.

bioRxiv · Apr 20, 2021 · PreprintMicrobiology

Non-canonical proline-tyrosine interactions with multiple host proteins regulate Ebola virus infection

J. Batra, M. Anantpadma, G. I. Small, O. Shtanko, M. Zhang, D. Liu, C. G. Williams, N. Biedenkopf, S. Becker, M. L. Gross, D. W. Leung, R. A. Davey, G. K. Amarasinghe, N. J. Krogan, C. F. Basler

This study identifies non-canonical proline-tyrosine interactions in the Ebola virus VP30 protein that regulate viral replication by interacting with multiple host proteins.

bioRxiv · May 19, 2020Microbiology

Pyronaridine Tetraphosphate Efficacy Against Ebola Virus Infection in Guinea Pig

T. R. Lane, C. Massey, J. E. Comer, A. N. Freiberg, H. Zhou, J. Dyall, M. Holbrook, M. Anantpadma, R. A. Davey, P. Madrid, S. Ekins

This paper evaluates pyronaridine tetraphosphate's efficacy against Ebola and Marburg viruses in guinea pigs, showing 40% survival and suggesting its potential for antiviral repurposing.

bioRxiv · Mar 20, 2020Pharmacology & Toxicology