Author

D. B. Sykes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6 Cell Biology· 2 Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:cell type annotation· 6 Organism:mouse· 6 Organism:human· 5 Assay:proteomics· 5 Research Focus:differential expression· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:cancer & tumor microenvironment· 3

Frequent Co-Authors

D. T. Scadden· 4 shared T. Hirz· 4 shared M. K. Mansour· 3 shared N. Baryawno· 3 shared S. Mei· 3 shared Y. Kfoury· 3 shared A. K. Scherer· 2 shared A. O. Subtelny· 2 shared

Activity by Year

2021-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersCancer Biology

D. T. Scadden

Mutual co-authors in cluster

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11 papers

Recent·Most cited

Androgen blockade primes NLRP3 in macrophages to induce tumor phagocytosis

K. K. Chaudagar, R. Srikrishnan, S. Mei, T. Hirz, Y.-M. Hu, A. Argulian, B. Labadie, K. Desai, S. Grimaldo, D. Kahramangil, R. Nair, S. D Souza, D. Zhou, M. Li, F. Doughan, , A. Patnaik

This study shows that androgen blockade increases NLRP3 in macrophages, which when combined with NLRP3 agonist, enhances cancer cell phagocytosis and tumor control in a mouse model of prostate cancer.

bioRxiv · Sep 15, 2023 · PreprintCancer Biology

DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation

N. J. Mullen, S. K. Shukla, R. Thakur, S. S. Kollala, D. Wang, N. Chaika, J. F. Santana, W. R. Miklavcic, D. A. LaBreck, J. R. Mallareddy, D. Price, A. Natarajan, K. Mehla, D. B. Sykes, M. A. Hollingsworth, P. K. Singh

This study shows DHODH inhibition enhances immune checkpoint blockade by increasing cancer cell antigen presentation through pyrimidine depletion and P-TEFb-mediated RNA polymerase II elongation.

bioRxiv · Apr 3, 2023Cancer Biology

Predestined neutrophil heterogeneity in homeostasis varies in transcriptional and phenotypic response to Candida

A. K. Scherer, A. Hopke, S. Xu, A. Viens, N. J. Alexander, K. D. Timmer, D. Archambault, D. Floyd, N. J. Atallah, C. Rhee, M. Cetinbas, D. Scadden, D. Irimia, D. B. Sykes, R. I. Sadreyev, M. K. Mansour

The paper shows that clonal neutrophil progenitors have predestined transcriptional and epigenetic heterogeneity that influences their response to Candida infections.

bioRxiv · Nov 1, 2022 · PreprintImmunology

Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress

B. T. Do, P. P. Hsu, S. Y. Vermeulen, Z. Wang, T. Hirz, K. L. Abbott, N. Aziz, J. M. Replogle, S. Bjelosevic, J. Paolino, S. Nelson, S. Block, A. M. Darnell, R. Ferreira, H. Zhang, , M. G. Vander Heiden

The paper shows that nucleotide depletion and DNA replication stress drive cell fate transitions in hematopoietic systems by activating lineage-specific maturation genes.

bioRxiv · Aug 16, 2022Cancer Biology

A new transcriptional metastatic signature predicts survival in clear cell renal cell carcinoma

A. M. Alchahin, S. Mei, I. Tsea, T. Hirz, Y. Kfoury, D. Dahl, C.-L. Wu, A. O. Subtelny, S. Wu, D. T. Scadden, J. H. Shin, P. J. Saylor, D. B. Sykes, P. V. Kharchenko, N. Baryawno

The paper identifies a transcriptional signature in primary ccRCC tumors that predicts metastatic potential and patient survival.

bioRxiv · Jun 28, 2022Cancer Biology

Brequinar and Dipyridamole in Combination Exhibits Synergistic Antiviral Activity Against SARS-CoV-2 in vitro: Rationale for a host-acting antiviral treatment strategy for COVID-19

J. F. Demarest, M. Kienle, R. Boytz, M. Ayres, E. Kim, D. Chung, V. Gandhi, R. A. Davey, D. B. Sykes, N. Shohdy, J. C. Pottage, V. S. Kumar

This study shows that combining brequinar and dipyridamole synergistically inhibits SARS-CoV-2 replication in vitro by depleting cellular pyrimidine nucleotides.

bioRxiv · Mar 30, 2022Microbiology

Integrated single-cell and spatial transcriptomic analyses unravel the heterogeneity of the prostate tumor microenvironment

T. Hirz, S. Mei, H. Sarkar, Y. Kfoury, S. Wu, B. M. Verhoeven, A. O. Subtelny, D. V. Zlatev, M. W. Wszolek, K. Salari, E. Murray, F. Chen, E. Z. Macosko, C.-L. Wu, D. T. Scadden, , D. B. Sykes

This study uses single-cell and spatial transcriptomic analyses to characterize the prostate tumor microenvironment, revealing immune suppression and high angiogenic activity.

bioRxiv · Mar 18, 2022 · PreprintCancer Biology

DHODH is an independent prognostic marker and potent therapeutic target in neuroblastoma

T. K. Olsen, C. Dyberg, B. Embaie, A. Alchahin, J. Milosevic, J. Otte, C. Tummler, I. H. Myrberg, E. M. Westerhout, J. Koster, R. Versteeg, P. Kogner, J. I. Johnsen, D. B. Sykes, N. Baryawno

This study identifies DHODH as a prognostic marker and therapeutic target in neuroblastoma, showing its inhibition improves survival in preclinical models and suggests combination therapy with temozolomide.

bioRxiv · Sep 25, 2021Cancer Biology

tiRNA signaling via stress-regulated vesicle transfer in the hematopoietic niche

Y. Kfoury, F. Ji, M. Mazzola, D. B. Sykes, A. K. Scherer, A. Anselmo, Y. Akiyama, F. Mercier, N. Severe, K. D. Kokkaliaris, T. Brouse, J. Seidl, A. Papzian, P. Ivanov, M. K. Mansour, , D. T. Scadden

The paper shows that stress-induced extracellular vesicles transfer tiRNAs to hematopoietic progenitors, enhancing myeloid recovery and survival.

bioRxiv · Apr 13, 2021Cell Biology

Neutrophils require SKAP2 for reactive oxygen species production following C-type lectin and Candida stimulation

G. T. Nguyen, S. Xu, S. C. Bunnell, M. K. Mansour, D. B. Sykes, J. Mecsas

This study shows SKAP2 is essential for neutrophil ROS production in response to C-type lectin receptors and Candida infections, expanding its role beyond antibacterial immunity.

bioRxiv · Mar 2, 2021Immunology

Cyclophilin A regulates protein phase separation and mitigates haematopoietic stem cell aging

L. Maneix, P. Iakova, S. E. Moree, J. C. K. King, D. B. Sykes, C. T. Hill, B. Saez, E. Spooner, D. S. Krause, E. Sahin, B. C. Berk, D. T. Scadden, A. Catic

This study identifies Cyclophilin A as a key regulator of protein phase separation and shows its role in mitigating haematopoietic stem cell aging.

bioRxiv · Feb 24, 2021Cell Biology