IMPDH1 retinal variants control filament architecture to tune allosteric regulation
A. L. BURRELL, C. Nie, M. Said, J. C. Simonet, D. Fernandez-Justel, M. C. Johnson, J. Quispe, R. M. Buey, J. R. Peterson, J. M. Kollman
The paper shows IMPDH1 retinal variants form different filaments that affect GTP regulation, with disease mutations disrupting or not affecting this regulation.
bioRxiv · Aug 3, 2021Biochemistry