Author

J. C. Woodard

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Biophysics· 1

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Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Assay:protein structure· 1

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W. Zheng· 1 shared Y. Zhang· 1 shared

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2021-2021 · peak 1/yr

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1 shared paperBiophysics

W. Zheng

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1 paper

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BiophysicsbioRxivJul 8, 2021

Protein structural features predict responsiveness to pharmacological chaperone treatment for three lysosomal storage disorders

J. C. Woodard, W. Zheng, Y. Zhang

The paper uses structural and sequence data to predict responsiveness to pharmacological chaperone treatment for Gaucher disease variants, finding that protein topology and mutation stability influence treatment effectiveness.

DOI 10.1371/journal.pcbi.1009370

humanprotein structure

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