Regulation of Iron Homeostasis Through Parkin-mediated Lactoferrin Ubiquitylation
A. A. Gholkar, S. Schmollinger, E. F. Velasquez, Y.-C. Lo, W. Cohn, J. Capri, H. Dharmarajan, W. J. Deardorff, L. W. Gao, M. Abdusamad, J. P. Whitelegge, J. Z. Torres
This study shows Parkin binds and ubiquitylates lactotransferrin to regulate iron homeostasis, linking Parkin dysfunction to Parkinson's disease.
bioRxiv · Jun 4, 2020Biochemistry