Author

J. P. Whitelegge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. A. Gholkar· 3 shared E. F. Velasquez· 3 shared J. Z. Torres· 3 shared W. Cohn· 3 shared L. W. Gao· 2 shared S. S. Hasan· 2 shared Y. A. Garcia· 2 shared A. Gomez· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersBiochemistry

A. A. Gholkar

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A single C-terminal residue controls SARS-CoV-2 spike trafficking and virion assembly

D. Dey, E. Qing, Y. He, Y. Chen, B. Jennings, W. Cohn, S. Singh, L. Gakhar, N. J. Schnicker, B. G. Pierce, J. P. Whitelegge, B. Doray, J. P. Orban, T. Gallagher, S. S. Hasan

This study identifies a C-terminal residue critical for SARS-CoV-2 spike protein trafficking and virion assembly, offering insights for vaccine design.

bioRxiv · Mar 9, 2023 · PreprintBiophysics

BCN057, a Modulator of GSK3β Induces KRAS G12D Mutant Pancreatic Cancer Cell Death

E. M. Singer, R. M. Chugh, P. Bhanja, A. Gomez, L. Gao, J. P. Whitelegge, W. H. McBride, S. Saha, A. J. Norris

This paper shows that BCN057, a GSK3β modulator, selectively induces apoptosis in KRAS G12D mutant pancreatic cancer cells while protecting normal intestinal epithelium.

bioRxiv · Sep 3, 2021 · PreprintCancer Biology

DUSP7 Regulates the Activity of ERK2 to PromoteProper Chromosome Alignment During Cell Division

X. Guo, Y. A. Garcia, I. Ramirez, E. F. Velasquez, L. W. Gao, A. A. Gholkar, J. P. Whitelegge, B. Tofig, R. Damoiseaux, J. Z. Torres

This study shows DUSP7 regulates ERK2 activity to ensure proper chromosome alignment during cell division, preventing aneuploidy and tumorigenesis.

Journal of Biological Chemistry · Jan 1, 2021Peer-reviewedCell Biology

Dissection of the Spindle Assembly Checkpoint by Proximity Proteomics

Y. A. Garcia, E. F. Velasquez, L. A. Gao, K. Cheung, K. M. Clutario, T. Williams-Hamilton, A. A. Gholkar, J. P. Whitelegge, J. Z. Torres

The paper uses proximity proteomics to map the spatial associations of core SAC proteins during prometaphase, revealing known and novel interactions.

bioRxiv · Jun 4, 2020 · PreprintBiochemistry

Regulation of Iron Homeostasis Through Parkin-mediated Lactoferrin Ubiquitylation

A. A. Gholkar, S. Schmollinger, E. F. Velasquez, Y.-C. Lo, W. Cohn, J. Capri, H. Dharmarajan, W. J. Deardorff, L. W. Gao, M. Abdusamad, J. P. Whitelegge, J. Z. Torres

This study shows Parkin binds and ubiquitylates lactotransferrin to regulate iron homeostasis, linking Parkin dysfunction to Parkinson's disease.

bioRxiv · Jun 4, 2020Biochemistry

A Novel Chloroplast Super-Complex Consisting of the ATP Synthase and Photosystem I Reaction Center

S. Bhaduri, S. K. Singh, W. Cohn, S. S. Hasan, J. P. Whitelegge, W. A. Cramer

The paper identifies a novel chloroplast super-complex containing ATP synthase and photosystem I in the non-appressed stromal domain of thylakoid membranes.

bioRxiv · Dec 25, 2019Biochemistry