The integrated stress response mediates type I interferon driven necrosis in Mycobacterium tuberculosis granulomas
B. Bhattacharya, S. Xiao, S. Chatterjee, M. Urbanowski, A. Ordonez, E. A. Ihms, G. Agrahari, S. Lun, R. Berland, A. Pichugin, Y. Gao, J. Connor, A. Ivanov, B.-S. Yan, L. Kobzik, , I. Kramnik
This study identifies the integrated stress response (ISR) as a mediator of necrosis in tuberculosis granulomas, showing that ISR inhibition reduces bacterial burden and necrosis in susceptible mice.
bioRxiv · Dec 19, 2018 · PreprintImmunology