A. Ordonez

A genome wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α

The paper uses a CRISPR/Cas9 screen to identify calreticulin as a repressor of ATF6α signaling in the unfolded protein response.

Ecological Network Resilience & Extinction Proxies - Updating Projections of Ecological Networks

The paper introduces a framework to assess ecological network resilience and extinction risks under climate change, showing current methods underestimate ecological change.

Sex differences in lung imaging and SARS-CoV-2 antibody responses in a COVID-19 golden Syrian hamster model

This study shows that male golden Syrian hamsters experience more severe lung disease and lower antiviral antibody responses compared to females after SARS-CoV-2 infection.

Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers

This study identifies genes and cargo receptors involved in the ER export of pathogenic α1-antitrypsin polymers using a CRISPR screen.

Development of a small molecule that corrects misfolding and increases secretion of Z α1-antitrypsin

This study identifies a small molecule that stabilizes Z α1-antitrypsin, reduces polymerization, and increases its secretion in cells and mice.

A signal of competitive dominance in mid-latitude herbaceous plant communities

The paper analyzes plant distribution and trait data across Europe to show that plant height clustering relates to evapotranspiration and gross primary productivity, indicating interspecies competition in mid-latitude regions.

The integrated stress response mediates type I interferon driven necrosis in Mycobacterium tuberculosis granulomas

This study identifies the integrated stress response (ISR) as a mediator of necrosis in tuberculosis granulomas, showing that ISR inhibition reduces bacterial burden and necrosis in susceptible mice.