J. Cowgill

Divergent mechanisms of steroid inhibition in the human {rho}1 GABA(A) receptor

The paper characterizes the inhibitory mechanisms of two neuroactive steroids at the human {rho}1 GABAA receptor using cryo-EM, electrophysiology, and molecular dynamics simulations.

Structural Basis for Hyperpolarization-dependent Opening of the Human HCN1 Channel

The paper presents cryo-EM structures of human HCN1 in different states to elucidate the structural basis for hyperpolarization-dependent opening of the channel.

Structure and dynamics of differential ligand binding in the human {rho}-type GABA(A) receptor

This study presents cryo-EM structures of the human ρ1 GABAAR under different conditions, revealing structural mechanisms of gating and modulation with implications for pharmaceutical design.

Charge-voltage curves of Shaker potassium channel are not hysteretic at steady state

This paper shows that hysteresis in Shaker potassium channel charge-voltage curves is eliminated with long test pulses, indicating it is a kinetic, not thermodynamic, phenomenon.

Interplay between VSD, pore and membrane lipids in electromechanical coupling in HCN channels

This study investigates the electromechanical coupling in HCN channels by simulating the interplay between voltage-sensor domains, pore regions, and membrane lipids.