Y. Zhuang

E protein control of NKgammadeltaT cell development through both generation and function of the stereotypic Vgamma1Vdelta6.3 TCR

This study shows that Id3 deficiency affects the development of gamma delta T cell subsets by regulating the generation and function of the Vgamma1Vdelta6.3 TCR.

Symmetry-adapted Markov state models of closing, opening, and desensitizing in α7 nicotinic acetylcholine receptors

This study uses symmetry-adapted Markov state modeling to analyze conformational transitions in α7 nAChRs, revealing lipid modulation effects and asymmetric transition pathways between functional states.

Structure and dynamics of differential ligand binding in the human {rho}-type GABA(A) receptor

This study presents cryo-EM structures of the human ρ1 GABAAR under different conditions, revealing structural mechanisms of gating and modulation with implications for pharmaceutical design.

Spatially-resolved single-cell atlas of ascidian endostyle provides insights into the origin of vertebrate pharyngeal organs

The paper constructs a spatially-resolved single-cell atlas of the ascidian endostyle, identifying new cell types and evolutionary insights into vertebrate pharyngeal organs.

Illumination of the complement receptors C3aR and C5aR signaling by anaphylatoxins

This study reports the structures of C3a-bound C3aR and C5a-bound C5aR1, revealing their ligand recognition and activation mechanisms.

Structural Genomics of the Human Dopamine Receptor System

This study reports cryo-EM structures of all human dopamine receptor subtypes bound to Rotigotine, revealing binding modes, activation mechanisms, and G-protein coupling specificity for drug design.

Ancient DNA Reveals China as a Historical Genetic Melting Pot in Tiger Evolution

This study uses ancient DNA to trace tiger evolution, revealing China as a genetic melting pot and resolving taxonomic disputes among tiger subspecies.

A comprehensive single cell data analysis of in lymphoblastoid cells reveals the role of Super-enhancers in maintaining EBV latency

This study uses scRNA-seq to analyze EBV latency in lymphoblastoid cells, identifying two distinct clusters with different EBV gene expression and revealing the role of super-enhancers in maintaining latency.

Differential interactions of resting, activated, and desensitized states of the α7 nicotinic acetylcholine receptor with lipidic modulators

This study characterizes the functional states of the α7 nicotinic acetylcholine receptor using computational methods, revealing state-dependent interactions with lipids and ligands.

AlphaFold2 and RoseTTAFold Predict Posttranslational modifications. Chromophore Formation in GFP-like Proteins.

This study shows AlphaFold2 and RoseTTAFold can predict whether GFP-like proteins will form a chromophore based on sequence alone, using structural and chemical insights.

Guiding Irregular Nuclear Morphology on Nanopillar Array for Malignancy Differentiation in Tumor cells

This paper uses nanopillar arrays to quantify subnuclear morphology in tumor cells, showing it correlates with malignancy and drug response.

New insights into colorectal cancer liver metastasis carcinogenesis and its effect with moxibustion

This study investigates the effect of moxibustion on colorectal cancer liver metastasis using animal models, finding reduced metastasis rates and identifying potential molecular targets.

Loss of Zfp335 triggers cGAS/STING-dependent apoptosis of post-β selection pre-T cells

This study identifies Zfp335 as a transcription factor that regulates survival of post-β-selection DN4 thymocytes by suppressing cGAS/STING-dependent apoptosis.

Serum Amyloid A promotes Acetaminophen-induced liverinjury by damaging sinusoidal endothelial cell and exacerbating platelet aggregation in liver

This study shows that Serum Amyloid A (SAA) worsens acetaminophen-induced liver injury by damaging sinusoidal endothelial cells and increasing platelet aggregation.

Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor

The paper presents cryo-EM structures of the ghrelin receptor bound to ghrelin and GHRP-6, revealing the binding pocket for the octanoyl group and providing insights for drug design.

Probing effects of the SARS-CoV-2 E protein on membrane curvature and intracellular calcium

This study investigates the SARS-CoV-2 E protein's effects on membrane curvature and intracellular calcium, using experimental and computational methods.

Vaccination-induced rapid protection against bacterial pneumonia via training alveolar macrophage in mice

This study shows a single intranasal vaccination with inactivated Acinetobacter baumannii rapidly protects mice against pneumonia by training alveolar macrophages, with effects observed against other Gram-negative bacteria but not Gram-positive ones.

Structural basis for ligand recognition and G protein-coupling promiscuity of the cholecystokinin A receptor

The paper presents cryo-EM structures of CCKAR with different G proteins to elucidate its G protein coupling promiscuity and ligand recognition mechanism.

pUL21 is a viral phosphatase adaptor that promotes herpes simplex virus replication and spread

This study identifies pUL21 as a viral phosphatase adaptor that promotes HSV-1 replication and spread by directing dephosphorylation and antagonizing pUS3 kinase activity.

A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes corpus luteum regression

This study shows that RIPK3 phosphorylation at S165/T166 switches its function from necroptosis to apoptosis, driving corpus luteum regression via PGF2-induced apoptosis.

Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations

The paper reports cryo-EM structures and simulations of GLIC under different pH conditions, revealing conformational changes and electrostatic remodeling during proton-induced gating.

Genomic Evidence for the Chinese Mountain Cat as a Wildcat Conspecific (Felis silvestris bieti) and Its Introgression to Domestic Cats

The paper uses genomic data to classify the Chinese mountain cat as a wildcat subspecies and finds no evidence of its role in domestic cat domestication in East Asia.

New cinnamid and rosmarinic acid-derived compounds biosynthesized in Escherichia coli as Leishmania amazonensis arginase inhibitors

The paper describes the biosynthesis of new cinnamid and rosmarinic acid-derived compounds in E. coli that inhibit Leishmania amazonensis arginase, with some compounds showing micromolar inhibition.

Early induction of SARS-CoV-2 specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients

The paper examines the relationship between SARS-CoV-2 specific T cell responses and disease severity in COVID-19 patients, finding that early T cell induction correlates with mild disease and faster viral clearance.

MicroRNA775 Promotes Intrinsic Leaf Size and Reduces Cell Wall Pectin Level via a Target Galactosyltransferase in Arabidopsis

This study identifies miR775 as a regulator of leaf size in Arabidopsis by silencing GALT9, a galactosyltransferase that affects cell wall pectin levels and elasticity.

Celastrol directly inhibits PFKM to induce weight loss and leptin sensitization

This study identifies PFKM as a direct target of celastrol, showing that its inhibition promotes weight loss and leptin sensitivity through AMPK/ACC signaling.

Comparative study of curvature sensing mediated by F-BAR domain and an intrinsically disordered region of FBP17

This study shows that the intrinsically disordered region of FBP17, not its F-BAR domain, is responsible for curvature sensing in membrane dynamics.

The PIF1-MIR408-Plantacyanin Repression Cascade Regulates Light Dependent Seed Germination

The paper identifies a PIF1-MIR408-PLC repression cascade that links light-induced PIF1 degradation to hormonal changes, regulating seed germination in Arabidopsis.

A Targeted Vaccine against COVID-19: S1-Fc Vaccine Targeting the Antigen-Presenting Cell Compartment Elicits Protection against SARS-CoV-2 Infection

This paper develops a S1-Fc vaccine targeting antigen-presenting cells, showing it elicits protective anti-SARS-CoV-2 IgG and T cell responses, with high protection at low doses.

Characterization of the dynamic resting state of a pentameric ligand-gated ion channel by cryo-electron microscopy and simulations

The paper uses cryo-EM and simulations to characterize the resting and activating states of GLIC, revealing structural changes and energy landscape dynamics.