P. Yuan

ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism

This study identifies ACAD10 and ACAD11 as enzymes critical for metabolizing 4-hydroxy fatty acids in mammals, revealing their unique mechanisms and subcellular localization.

Structural Basis for Hyperpolarization-dependent Opening of the Human HCN1 Channel

The paper presents cryo-EM structures of human HCN1 in different states to elucidate the structural basis for hyperpolarization-dependent opening of the channel.

Structure and function of the human mitochondrial MRS2 channel

This study investigates the structure and function of the human MRS2 channel, revealing its Ca2+-regulated, non-selective ion permeability and a conserved arginine ring that prevents proton motive force collapse.

Structural mechanism of leaflet-specific phospholipid modulation of a pentameric ligand-gated ion channel

The paper shows phosphatidylglycerol stabilizes the open state of ELIC by binding to a specific outer leaflet site, identified through structural and functional analyses.

Single-cell transcriptome reveals the redifferentiation trajectories of the early stage of de novo shoot regeneration in Arabidopsis thaliana

The paper uses single-cell transcriptomics to study cell fate transitions during early de novo shoot regeneration in Arabidopsis, identifying redifferentiation trajectories and regulatory factors.

Emergence of distinct and heterogeneous strains of amyloid beta as Alzheimer s disease progresses in Down syndrome

This study identifies distinct and heterogeneous amyloid beta strains in Down syndrome patients with advanced Alzheimer's disease, suggesting unique pathogenic mechanisms compared to sporadic Alzheimer's.

Cryo-EM structure of a proton-activated chloride channel TMEM206

The paper reports the cryo-EM structure of pufferfish TMEM206, revealing its trimeric architecture and chloride ion selectivity, and compares it to sodium channels despite sequence differences.

Cryo-EM structures of the ATP release channel pannexin 1

This study presents cryo-EM structures of pannexin 1 from Xenopus tropicalis and Homo sapiens, revealing its heptameric architecture and molecular sieve mechanism for ATP release.

3D super-resolution deep-tissue imaging in living mice

This paper develops a STED system for 3D super-resolution imaging in living mice, achieving depths of 76 micrometers in brain tissue.

Circular RNA hsa_circ_0068033 inhibits proliferation and invasion of breast cancer cells through sponging miR-659

Non-Canonical Regulation of Phosphatidylserine Metabolism by a Phosphatidylinositol Transfer Protein and a Phosphatidylinositol 4-OH Kinase

The paper shows that Psd2-dependent phosphatidylethanomaine production in yeast relies on Psd2, Sfh4, and Stt4, with Sfh4 activating the pathway through a physical interaction rather than its PtdIns transfer activity.

Atomistic basis of opening and conduction in mammalian inward rectifier potassium (Kir2.2) channels

The paper investigates the open conformation and K+ ion conduction mechanism in Kir2.2 channels using a forced open mutation and structural analysis.

The role of Cdx2 as a lineage specific transcriptional repressor for pluripotent network during trophectoderm and inner cell mass specification

This study identifies CDX2-regulated genes and regulatory elements in mouse embryos, revealing how CDX2 represses pluripotent genes during trophectoderm and inner cell mass specification.