Author

J. D. Beckham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:chromatin & epigenetic regulation· 1 Assay:flow cytometry· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

B. M. Akiyama· 2 shared J. S. Kieft· 2 shared M. E. Graham· 2 shared B. Akiyama· 1 shared B. Monogue· 1 shared C. Merrick· 1 shared D. S. Fader· 1 shared H. Sparks· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersMicrobiology

B. M. Akiyama

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Zika virus dumbbell-1 structure is critical for sfRNA presence and cytopathic effect during infection

M. E. Graham, C. Merrick, B. M. Akiyama, M. Szucs, S. Leach, J. S. Kieft, J. D. Beckham

This study shows that the ZIKV DB-1 RNA structure is critical for sfRNA levels, cytopathic effect, interferon resistance, and pathogenesis in mice.

bioRxiv · Jan 23, 2023Microbiology

Three-dimensional structure of a flavivirus dumbbell RNA reveals molecular details of an RNA regulator of replication

B. M. Akiyama, M. E. Graham, Z. O'Donoghue, J. D. Beckham, J. S. Kieft

The paper determines the 3D structure of a flavivirus dumbbell RNA, revealing its pseudoknot and how it regulates viral replication and translation.

bioRxiv · Sep 17, 2020Microbiology

Disruption of Zika virus xrRNA1-dependent sfRNA1 production results in tissue-specific attenuated viral replication

H. Sparks, B. Monogue, B. Akiyama, J. Kieft, J. D. Beckham

This study shows that disrupting sfRNA1 production in ZIKV reduces viral replication in brain and placenta but not spleen, while still inducing neutralizing antibodies.

bioRxiv · Sep 10, 2020Microbiology

Pregnancy alters innate immune responses to Zika virus infection in the genital tract

K. E. Lesteberg, D. S. Fader, J. D. Beckham

This study shows that pregnancy alters innate immune responses to Zika virus infection in mice, increasing tolerance and reducing IL-12 secretion from immune cells.

bioRxiv · Nov 2, 2019Immunology