J. S. Kieft

The paper presents bioinformatic and biochemical data showing structural differences in the 5' domain of tyrosine-accepting tRNA-like structures (TLSTyrs) between hordeiviruses and bromoviruses, highlighting modularity and functional conservation.

This paper introduces a scaffold-based cryo-EM method to determine RNA structures, achieving 4.5-5.0 Å resolution for sub-25 kDa RNA domains.

This paper identifies conserved ribosome-binding mechanisms in β-coronavirus Nsp1 proteins and shows how a cis-acting RNA element modulates Nsp1 function.

This study shows that the ZIKV DB-1 RNA structure is critical for sfRNA levels, cytopathic effect, interferon resistance, and pathogenesis in mice.

This paper introduces two improved methods for large-scale cultivation of Giardia lamblia trophozoites, addressing cost and complexity issues in previous approaches.

The paper uses cryo-EM to visualize a long-lived misfolded state in the folding pathway of a catalytic RNA, revealing its structural features and implications for RNA folding mechanisms.

The paper shows that marrow-mediated activation of ATM and mTOR increases oxidative phosphorylation, leading to resistance in FLT3 mutant AML cells, and that combining mTOR and FLT3 inhibitors reduces tumor burden.

The paper identifies new histidine-accepting tRNA-like structures in viral RNA genomes, expands their known diversity, and validates their structural and functional properties.

The paper uses cryo-EM to visualize a viral RNA mimic bound to host enzyme, revealing structural dynamics and noncanonical interactions that enable viral hijacking of host machinery.

The paper determines the 3D structure of a flavivirus dumbbell RNA, revealing its pseudoknot and how it regulates viral replication and translation.

The paper identifies a new subclass of exoribonuclease resistant RNA (xrRNA) in multiple Flaviviridae genera, expanding the known distribution and structural diversity of xrRNAs.

The paper identifies an xrRNA in Tamana Bat Virus and shows it achieves a conserved 3D structure through novel tertiary interactions, highlighting sequence and structural diversity in flaviviruses.

The paper investigates the structural diversity and phylogenetic distribution of valyl tRNA-like structures in viruses, identifying structural heterogeneity and cases of anticodon switching.

The paper presents the crystal structure of a polerovirus xrRNA, revealing sequence diversity within a conserved fold and explaining conservation patterns and new interactions.

The paper shows that RNA matchmaking between HOTAIR and target gene RNAs relieves PRC2 inhibition, promoting its activity through structural changes and hnRNP B1-mediated interactions.

The paper identifies a novel RNA structure-dependent mechanism in dianthoviruses that blocks exoribonucleases, revealing convergent evolution of xrRNAs across unrelated viral families.