Negative allosteric modulation of CB1 cannabinoid receptor signaling decreases intravenous morphine self-administration and relapse in mice
I. Oliva, F. A. Kazi, L. N. Cantwell, G. A. Thakur, J. D. Crystal, A. G. Hohmann
This study shows that negative allosteric modulation of CB1 receptors reduces morphine self-administration and relapse in mice without affecting food reward motivation.
bioRxiv · Jan 16, 2024 · PreprintAnimal Behavior & Cognition