High-throughput screening identifies small molecule inhibitors of thioesterase superfamily member 1: Implications for the management of non-alcoholic fatty liver disease
C. S. Krumm, L. Ramos-Espiritu, R. S. Landzberg, C. Adura, X. Liu, M. Acuna, Y. Xie, X. Xu, M. C. Tillman, Y. Li, F. Glickman, E. A. Ortlund, J. D. Ginn, D. E. Cohen
This study identifies small molecule inhibitors of Them1, showing they enhance fatty acid oxidation and reduce glucose production in liver cells, suggesting therapeutic potential for NAFLD.
Molecular Metabolism · Dec 1, 2023Peer-reviewedPharmacology & Toxicology