Maternal Western-Style Diet Impairs Bone Marrow Development and Drives a Hyperinflammatory Phenotype in Hematopoietic Stem and Progenitor Cells in Fetal Rhesus Macaques
S. Sureshchandra, C. N. Chan, J. J. Robino, L. K. Parmelee, M. J. Nash, S. R. Wesolowski, E. M. Pietras, J. E. Friedman, D. Takahashi, W. Shen, J. D. Hennebold, D. Goldman, W. Packwood, J. R. Lindner, C. T. Roberts, , O. Varlamov
This study shows that a maternal Western-style diet impairs fetal bone marrow development and causes hyperinflammation and B-cell dysfunction in fetal hematopoietic stem and progenitor cells in rhesus macaques.
bioRxiv · Apr 26, 2021 · PreprintImmunology