Author

C. E. Geisler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:metabolism & bioenergetics· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

B. J. Renquist· 3 shared S. Ghimire· 3 shared J. Yoshino· 2 shared K. E. Miller· 2 shared S. Klein· 2 shared A. de Araujo· 1 shared A. J. Alberto· 1 shared B. M. Krusen· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersPhysiology

B. J. Renquist

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Author profile →

4 papers

Recent·Most cited

Hepatic Vagal Afferents Convey Clock-Dependent Signals to Regulate Circadian Food Intake

L. N. Woodie, L. C. Melink, M. Midha, A. de Araujo, C. E. Geisler, A. J. Alberto, B. M. Krusen, D. M. Zundell, G. de Lartigue, M. R. Hayes, M. A. Lazar

The paper shows that hepatic vagal afferents transmit circadian signals between the liver and brain, influencing food intake and body weight.

bioRxiv · Nov 30, 2023Physiology

A Critical Role of Hepatic GABA in The Metabolic Dysfunction and Hyperphagia of Obesity

C. E. Geisler, S. Ghimire, S. M. Bruggink, K. E. Miller, S. N. Weninger, J. M. Kronenfeld, J. Yoshino, S. Klein, F. A. Duca, B. J. Renquist

This study shows that inhibiting hepatic GABA production in obese mice reduces hyperinsulinemia, improves glucose tolerance, and decreases food intake, suggesting a role for hepatic GABA in obesity-related metabolic dysfunction.

bioRxiv · Apr 2, 2020Physiology

Hepatocyte Membrane Potential Regulates Serum Insulin and Insulin Sensitivity by Altering Hepatic GABA Release

C. E. Geisler, S. Ghimire, C. Hepler, K. E. Miller, M. R. Higgins, J. Yoshino, S. Klein, B. J. Renquist

This study identifies GABA as a novel hepatokine dysregulated in obesity, showing that hepatic GABA release affects serum insulin and insulin sensitivity.

bioRxiv · Apr 2, 2020Physiology

TMEM135 is an LXR-Inducible Regulator of Peroxisomal Metabolism

B. J. Renquist, T. W. Madanayake, J. D. Hennebold, S. Ghimire, C. E. Geisler, Y. Xu, R. L. Bogan

This study identifies TMEM135 as an LXR target gene that regulates peroxisomal metabolism, showing impaired β-oxidation in its knockdown.

bioRxiv · Jun 3, 2019 · PreprintCell Biology