Screening of yeast display libraries of enzymatically-cyclized peptides to discover macrocyclic peptide ligands
J. D. Bowen, J. D. Schneible, C. R. Labar, S. Menegatti, B. M. Rao
The paper develops methods to cyclize peptides using transglutaminase in yeast display libraries and identifies cyclic peptides that bind YAP and its WW domains with high selectivity.
bioRxiv · Aug 8, 2020Biochemistry