Measuring integrin force loading rates using a two-step DNA tension sensor
J. Dale Combs, Alexander K. Foote, Hiroaki Ogasawara, Arventh Velusamy, Sk Aysha Rashid, Joseph Nicholas Mancuso, Khalid S. Salaita
This paper develops a DNA tension sensor to measure integrin force loading rates in live cells, revealing exponential decay in bond lifetime and localized high-force events at cell-substrate junctions.
Journal of the American Chemical Society · Aug 12, 2024Peer-reviewedCell Biology