A PTP1B-Cdk3 signaling axis promotes cell cycle progression of human glioblastoma cells through an Rb-E2F dependent pathway
O. Villamar-Cruz, M. A. Loza-Mejia, A. Vivar-Sierra, H. I. Saldivar-Ceron, G. Patino-Lopez, J. E. Olguin, L. I. Terrazas, L. Armas-Lopez, F. Avila-Moreno, S. Saha, J. Chernoff, I. Camacho-Arroyo, L. E. Arias-Romero
This study identifies a PTP1B-Cdk3 signaling axis that promotes glioblastoma cell cycle progression via Rb-E2F pathway, showing PTP1B dephosphorylates Cdk3 and inhibits its activity.
bioRxiv · Jun 14, 2022Cancer Biology